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. 2012 Sep 19;7(9):e43634. doi: 10.1371/journal.pone.0043634

Figure 2. A dose of 1.0 mg/kg of Rolipram provides optimal protection of cells and axons following SCI.

Figure 2

Animals were treated with doses of Rolipram ranging from 0.1 mg/kg to 5.0 mg/kg (white bars). Total counts of NeuN+ neurons (A) or APC-CC1+ oligodendrocytes (B) within rostral and caudal segments as well as CMAs (C) from the injury epicenter, showed that a dose of 1.0 mg/kg Rolipram was optimal for the preservation of axons and cells following SCI. Statistical significance indicated at *p<0.05 or **p<0.01 compared to injury only controls (gray bar) and #p<0.05 or ##p<0.01 compared to vehicle controls (black bar). Error bars are expressed as SEMs.