Figure 1. Loss of CCR7-expressing CD56^bright NK cells correlates with clinical disease markers.

(A) Representative flow cytometry plots defining CD56^bright NK cells. Numbers indicate percentage of the gated population. (B) Representative CCR7, CD62L, CXCR3 and CD16 expression data and summary data all gated on CD56^bright NK cells. Horizontal bars in dot plot indicate mean values. (C) Pearson’s correlation analysis between frequencies of either CD62L⁺ or CD16⁺CD56bright NK cells and CCR7⁺CD56^bright NK cells in untreated HIV-seropositive patients. (D) Pearson’s correlation analysis between frequencies of CCR7⁺, CD62L⁺, CXCR3⁺ or CD16⁺ cells of total CD56^bright NK cells with either viral load or CD4⁺ T cell counts in untreated HIV-positive subjects. *, P<0.05; ***, P<0.001; NS – not significant.