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Meta-analysis of the risk of bladder cancer associated with the use of any thiazolidinedione in randomized controlled trials (A) and cohort studies (B). A value greater than 1.0 indicates an increased risk of bladder cancer with the use of any thiazolidinedione. *A total of 178 cases of bladder cancer occurred in the study population. †Pioglitazone; ‡rosiglitazone. CI = confidence interval, NR = not reported.
