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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Exp Hematol. 2012 Jun 9;40(10):800–810. doi: 10.1016/j.exphem.2012.06.001

Figure 3.

Figure 3

Activation of the ATM-CHK2 and ATR-CHK1 pathways in cells exposed to various combinations of busulfan-melphalan-gemcitabine-SAHA (B±M±G±S). J45.01 cells were continuously exposed to drugs for 48 hr and total protein extracts were analyzed for phosphorylation of ATM and ATR and their known substrates. B: 20 μM busulfan; M: 0.7 μM melphalan; G: 0.01 μM gemcitabine; S: 0.6 μM suberoylanilide hydroxamic acid.