Table 2.

Hazard ratio (95% confidence interval) for non-spine, hip, and non-spine non-hip fracture by category of femoral neck and total hip BMD change

Change in Femoral neck BMD
	Multivariate model (Base Model)*	Base Model + baseline BMD	Base Model + visit 2 BMD
Non-spine fracture
Maintained	1.00 (referent)	1.00 (referent)	1.00 (referent)
Expected loss	1.11 (0.85, 1.45)	1.08 (0.83, 1.41)	0.89 (0.68, 1.16)
Accelerated loss	1.98 (1.42, 2.75)	2.06 (1.48, 2.87)	1.34 (0.95, 1.89)
Hip fracture
Maintained	1.00 (referent)	1.00 (referent)	1.00 (referent)
Expected loss	2.41 (1.08, 5.37)	2.41 (1.08, 5.36)	1.52 (0.68, 3.41)
Accelerated loss	6.28 (2.66, 14.81)	7.19 (3.04, 17.03)	2.63 (1.08, 6.38)
Non-hip, non-spine fracture
Maintained	1.00 (referent)	1.00 (referent)	1.00 (referent)
Expected loss	1.00 (0.76, 1.32)	0.98 (0.74, 1.29)	0.84 (0.63, 1.11)
Accelerated loss	1.56 (1.08, 2.25)	1.61 (1.11, 2.32)	1.15 (0.78, 1.68)
Change in Total hip BMD
Non-spine fracture
Maintained	1.00 (referent)	1.00 (referent)	1.00 (referent)
Expected loss	1.13 (0.87, 1.47)	1.15 (0.89, 1.50)	0.99 (0.76, 1.29)
Accelerated loss	1.92 (1.37, 2.69)	1.89 (1.35, 2.64)	1.32 (0.93, 1.88)
Hip fracture
Maintained	1.00 (referent)	1.00 (referent)	1.00 (referent)
Expected loss	1.87 (0.90, 3.89)	2.06 (0.99, 4.30)	1.53 (0.74, 3.20)
Accelerated loss	6.10 (2.74, 13.59)	6.20 (2.79, 13.76)	3.08 (1.36, 6.98)
Non-hip, non-spine fracture
Maintained	1.00 (referent)	1.00 (referent)	1.00 (referent)
Expected loss	1.10 (0.83, 1.46)	1.12 (0.85, 1.48)	0.99 (0.75, 1.31)
Accelerated loss	1.51 (1.03, 2.21)	1.48 (1.01, 2.17)	1.10 (0.74, 1.64)

^*Adjusted for age, race, presence of at least one medical condition at baseline, Physical Activity Scale for the Elderly score (PASE) at baseline, change in PASE score from baseline to Visit 2, weight at baseline, change in weight from baseline to Visit 2, self-rated health at baseline, and category of change in self-rated health from baseline to Visit 2.