Table 2.
Anesthetic Use and Recovery Variables
| Anesthetic concentration (N=9,376) | Bispectral Index (N=6,076) | No intervention (N=3,384) | p-value | |
|---|---|---|---|---|
|
| ||||
| BIS Values* | 40[34 to 46] | 40 [35 to 44] | N/A | NS |
| % complete data(n) | 41%(3,885) | 100%(6,076) | N/A | |
|
| ||||
| MAC Values** | 0.9 [0.8 to 1.1] | 0.9 [0.8 to 1.1] | 0.9 [0.8 to 1.1] | <0.001(Pairwise-comparisons of No Intervention to Anesthetic Concentration AND No intervention to BIS) |
| %complete data(n) | 98%(9,170) | 99%(5,988) | 98%(3,303) | |
|
| ||||
| Propofol Intraoperative Bolus (mg)** | 170 [130 to 200] | 180 [130 to 200] | 170 [120 to 200] | <0.001(Pair-wise comparison of No intervention to BIS) |
| % complete data(n) | 100%(9,376) | 100%(6,076) | 100%(3,384) | |
|
| ||||
| Midazolam (mg)** | 2 [2to 4] | 2 [2to 4] | 2 [2to 4] | NS |
| % complete data(n) | 100%(9,376) | 100%(6,076) | 100%(3,384) | |
|
| ||||
| Fentanyl (μg)** | 175 [100 to 250] | 200 [100 to 250] | 150 [100 to 250] | <0.001(All pairwise comparisons) |
| % complete data(n) | 100%(9,376) | 100%(6,076) | 100%(3,384) | |
|
| ||||
| Morphine (mg)** | 0 [0 to 5] | 0 [0 to 5] | 0 [0 to 3] | <0.001(All pairwise comparisons) |
| % complete data(n) | >99.9%(9,374) | >99.9%(6,074) | >99.9%(3,383) | |
|
| ||||
| PACU Discharge Readiness(min)** | 98 [66 to 140] | 95 [64 to 138] | 94 [64 to 133] | 0.001(Pairwise comparison No intervention to anesthetic concentration) |
| % complete data(n) | 91%(8,527) | 91%(5,521) | 90%(3,043) | |
|
| ||||
| No Nausea(% of patients)(n)*** | 92% (6,184) | 93% (4,042) | 93% (2,286) | NS |
| % complete data(n) | 72%(6,787) | 72%(4,403) | 74%(2,506) | |
|
| ||||
| No Vomiting(% of patients)(n) *** | 99% (7,149) | 99% (4,617) | 99% (2,608) | NS |
| % complete data(n) | 78%(7,329) | 77%(4,707) | 79%(2,687) | |
Note: Bonferroni adjustments were made due to post hoc comparisons (α =0.002). All data using the Kruskal-Wallis test also had pair-wise comparisons using a series of Mann-Whitney U tests if the omnibus test was significant. Only p-values < 0.002 in the pairwise comparisons were reported as statistically significant differences for these post hoc tests.
Nonparametric data presented as median [25th to 75th percentile interquartile] ranges and evaluated using Mann-Whitney U test.
Nonparametric data presented as median [25th to 75th percentile interquartile] ranges and evaluated using Kruskal-Wallis test.
Categorical data evaluated using Pearson chi-square.
BIS=Bispectral Index; MAC=minimum alveolar concentration; PACU=postanesthesia care unit.