Table 3.
Allele and genotype frequency distribution of C150T polymorphism of the inducible nitric oxide synthetase gene in Helicobacter pylori3 n (%)
| H. pylori+ | H. pylori- | OR2 | 95%CI | P-value | |
| iNOS C150T GC patients | n = 94 | n = 65 | |||
| CC | 44 (46.8) | 44 (67.7) | 1.001 | ||
| CT | 40 (42.6) | 19 (29.2) | 2.1 | 1.06-4.19 | 0.03 |
| TT | 10 (10.6) | 2 (3.1) | 5 | 1.03-24.14 | 0.029 |
| C | 128 (68.1) | 107 (82.3) | 1.001 | ||
| T | 60 (31.9) | 23 (17.7) | 2.2 | 1.26-3.76 | 0.004 |
| TT + CT | 50 (53.2) | 21 (32.3) | 2.4 | 1.23-4.6 | 0.01 |
| Controls | n = 77 | n = 93 | |||
| CC | 40 (51.9) | 52 (55.9) | 1.001 | ||
| CT | 36 (46.8) | 36 (38.7) | 1.3 | 0.7-2.41 | 0.41 |
| TT | 1 (1.3) | 5 (5.4) | 0.26 | 0.03-2.31 | 0.197 |
| C | 116 (75.3) | 140 (75.3) | 1.001 | ||
| T | 38 (24.7) | 46 (24.7) | 0.99 | 0.61-1.64 | 0.99 |
| TT + CT | 37 (48.05) | 41 (44.1) | 1.2 | 0.64-2.15 | 0.6 |
1
The first allele or genotype is the reference for statistical analysis;
2
Adjusted for age and gender; 3Infected or non-infected patients with and without GC. GC: Gastric cancer; iNOS: Inducible nitric oxide synthetase; CC: Homozygous CC genotype; CT: Heterozygous CT genotype; TT: Homozygous TT genotype; C: Number of individual C alleles in the group; T: Number of individual T alleles in the group; HWE: Hardy Weinberg Equilibrium; OR: Odds ratio; CI: Confidence interval; H. pylori: Helicobacter pylori.