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. 2012 Sep 12;2012:103032. doi: 10.1155/2012/103032

Table 3.

Second malignant neoplasm, standard incidence ratio, and absolute excess risk of young adult cancer by sexf.

Entire cohort (N = 1248) Male (N = 589) Female (N = 659)
Obsa Expb SMRc 95% CId AERe Obsa SIRb 95% CIc AERd Obsa SIRb 95% CIc AERd
Overall 62 21 3.0 2.3–3.8* 1.9 25 3.6 2.3–5.3* 1.9 37 2.7 1.9–3.7* 2.0
Type of original cancer
 Lymphoma 31 4.4 7.0 4.7–9.9* 5.3 12 6.5 3.4–11.4* 3.9 19 7.3 4.4–11.4* 6.7
 Germ cell tumor 7 2.3 3.1 1.2–6.3* 1.6 7 3.7 1.5–7.6* 1.9 0 0 N/A N/A
 Melanoma 6 3.4 1.7 0.6–3.8 0.7 0 0 N/A N/A 6 2.4 0.9–5.3 1.5
 Carcinomas 12 7.9 1.5 0.8–2.7 0.6 <5 2.7 0.6–7.9 1.4 9 1.3 0.6–2.5 0.4
 Otherse 6 2.9 2.1 0.8–4.5 1.0 <5 2.4 0.5–7.1 1.0 <5 1.5 0.3–4.3 0.6
Follow-up time (years)                
 5–19 years 30 2.6 11.6 7.9–16.6* 5.5 12 11.2 5.8–19.6* 4.7 18 12 7.1–18.9* 6.2
 +20 years 32 18.4 1.7 1.2–2.5* 0.8 13 2.2 1.2–3.7* 0.9 19 1.5 0.9–2.4 0.7
Diagnosis period
 1970–1979 32 12.7 2.5 1.7–3.5* 2.0 16 4.4 2.5–7.2* 3.3 16 1.8 1.0–2.9* 1.2
 1980–1989 24 6.7 3.6 2.3–5.3* 1.9 7 2.5 1.0–5.2* 0.9 17 4.3 2.5–6.9* 2.9
 1990–1995 6 1.5 4.0 1.5–8.7* 1.5 <5 3.1 0.4–11.3 0.9 <5 4.7 1.3–11.9* 1.9
Having chemotherapy                          
 Yes 24 3.8 6.3 4.1–9.4* 3.9 10 5.1 2.4–9.3* 2.6 14 7.7 4.2–12.9* 5.9
 No 29 9.4 3.1 2.1–4.4* 2.1 11 3.3 1.6–5.9* 1.7 18 3.0 1.8–4.7* 2.4
 Missing 9 7.8 1.2 0.5–2.2 0.2 <5 2.4 0.7–6.0 1.1 5 0.8 0.3–1.9 −0.2
Having radiation
 Yes 35 6.2 5.7 4–7.9* 4.5 14 5.2 2.9–8.8* 3.2 21 6.0 3.7–9.2* 6.0
 No 27 14.8 1.8 1.2–2.7* 0.8 11 2.5 1.3–4.5* 1.1 16 1.5 0.9–2.5 0.6
Having surgery                
 Yes 35 9.4 3.7 2.6–5.2* 2.5 12 3.1 1.6–5.4* 1.5 23 4.2 2.6–6.2* 3.5
 No 19 3.8 5.0 3.0–7.8* 3.5 10 6.7 3.2–12.3* 4.0 9 3.9 1.8–7.3* 3.1
 Missing 8 7.7 1.0 0.5–2.0 0.1 <5 1.8 0.4–5.2 0.6 5 0.8 0.3–1.9 −0.2
Major types of SMN                
 Digestive system 10 2 4.9 2.4–9.1* 0.4 9 9.7 4.4–18.3* 0.8 <5 0.9 0–5.1 0.0
 Respiratory system 7 1.1 6.2 2.5–12.8* 0.3 <5 7.0 1.4–20.5* 0.3 <5 5.7 1.6–14.6* 0.3
 Breast 18 5.1 3.6 2.1–5.6* 0.6 N/A N/A N/A N/A 18 3.6 2.1–5.6* 1.1
 Endocrine glands 6 1.2 5.0 1.8–10.8* 0.2 <5 9.2 1.1–33.2* 0.2 <5 4.0 1.1–10.3* 0.3
 Others 21 11.5 1.8 1.1–2.8* 0.1 11 2.0 1.0–3.6* 0.1 10 1.6 0.8–3.0 0.0

*P < 0.05.

aObs: number of observed deaths.

bSMR: standardized mortality ratio.

c95% CI: 95% confidence interval.

dAER: absolute excess risk, per 1,000 years at risk.

eOther types of original cancers include leukemia, central nervous system tumor, bone tumor, soft tissue sarcoma, and miscellaneous-specified tumor.

fTo protect confidentiality, all counts less than five are not specified.