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Response to PPARα agonists in aortas and MCAs of WT mice. Concentration-response curves to three different PPARα agonists (gemfibrozil, WY14643, and GW7647) in (a) mouse aortic rings precontracted with 10−5 M PGF2α by using isometric tension myography and (b) MCAs preconstricted with 10−5 M PE by using isobaric myography. All three PPARα agonists relaxed aortic rings (n = 3–5) as well as dilated the MCA (n = 7). Data are means ± SEM. *Indicates P ≤ 0.05.
