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. 2012 Sep 11;2012:302495. doi: 10.1155/2012/302495

Figure 5.

Figure 5

Exploration of the mechanism of PPARα agonist-mediated dilation in MCAs. (a) 10−5 M L-name and indomethacin pretreatment did not alter dilation to GW7647 in PE-preconstricted MCAs (n = 4). Likewise, in MCAs pretreated with high K+, dilation to GW7647 was again unaltered (n = 4). (b) In MCAs, pretreatment with phorbol 12,13-dibutyrate, as well as with 10−5 M ODQ (n = 5) impaired the dilatory response of GW7647 thereby implicating a role for PKC and sGC in the response (n = 3). Data are means ± SEM. *Indicates P ≤ 0.05.