Figure 1.

Effects of amyloid peptides on KP 1–54 and KP 45–54 release from SH-SY5Y neurons. Neuronal SHSY-5Y cell cultures were exposed to Aβ 1–42, Aβ 25–35, PrP 106–126, PrP 118–135, IAPP 1–37, IAPP 20–29, A-Bri 1–34, and A-Dan 1–34 peptides (50 nM each) for 2 h. The release of ir-KP 1–54 (A) and ir-KP 45–54 (B) into the cell culture media was determined by EIA. All results are expressed as the mean ± SEM (n = 8). (* = P < 0.05 vs control (media alone); one-way ANOVA.)