Skip to main content
. 2012 May 30;3(9):706–719. doi: 10.1021/cn300045d

Figure 2.

Figure 2

Effects of KP peptides on Aβ, PrP, A-Bri, A-Dan, and IAPP neurotoxicity in SH-SY5Y neurons. The effects of 10 μM KP 1–54 on the toxicity of Aβ 1–42, Aβ 1–40, Aβ 25–35, Aβ 29–40, Aβ 31–35, PrP 106–126, PrP 118–135, IAPP 1–37, IAPP 8–37, IAPP 20–29, A-Bri 1–34, and A-Dan 1–34 peptides (5 μM each) were tested in human SH-SY5Y neuroblastoma cell cultures (A), with cell viability determined by the MTT assay. The effects of KP 1–54, KP 27–54, KP 42–54, KP 45–54, KP 45–50, KP 45–47, KP 47–50, and NPFF peptides (10 μM each) on the toxicity of 5 μM Aβ 1–42 (B), 5 μM PrP 106–126 (C), and 5 μM IAPP 1–37 (D) were tested in human SH-SY5Y neuroblastoma cell cultures, with cell viability determined by the MTT assay. All results are expressed as a % control (SH-SY-5Y cells in media alone) and are expressed as the mean ± SEM (n = 8). (* = P < 0.05 vs control (media alone); † = P < 0.05 vs amyloid fibrils alone; one-way ANOVA.)