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. 2012 May 30;3(9):706–719. doi: 10.1021/cn300045d

Figure 3.

Figure 3

Effects of KP peptides on Aβ and PrP neurotoxicity in rat cortical neurons. The effects of 10 μM KP 42–54 (closed blue circles) or 10 μM KP 45–50 (closed red squares) on the toxicity of Aβ 1–42 (A) and PrP 106–126 (B) were tested in rat cortical neuron cell cultures, with cell viability determined by the MTT assay. The effects of 10 μM KP receptor antagonist P234 or 10 μM NPFF receptor antagonist RF9 on 2.5 μM KP 42–54 or 2.5 μM KP 45–50 protection against the toxicity of 5 μM Aβ 1–42 (C) and 5 μM PrP 106–126 (D) were tested in rat cortical neuron cell cultures, with cell viability determined by the MTT assay. All results are expressed as % control (rat cortical neurons in media alone) and are expressed as the mean ± SEM (n = 8). (* = P < 0.05 vs Aβ or PrP alone; † = P < 0.05 vs Aβ or PrP plus KP 42–54 or KP 45–50; one way ANOVA.)