Figure 3.
Changes in mechanical threshold to mechanical stimulus. Antiallodynic efficacies of intraperitoneal administration of A803467 and lidocaine to (A) diabetic and (B) nondiabetic rats. (C) Time course of mechanical allodynia after STZ treatment. Each point represents the mean value of 7 rats, and the vertical bars indicate 1 SD. D, time of drug injection; arrow, pretreatment value; *, significant (P < 0.05; Kruskal–Wallis repeated-measures ANOVA with Dunn multiple-comparison tests) difference from values of DMSO only and saline groups at each time point; #, significant (P < 0.05; Kruskal–Wallis repeated-measures ANOVA with Dunn multiple-comparison tests) difference from values after 10 mg/kg A803467 and 10 mg/kg lidocaine at each time point.