Table 1.
Major monofunctional alkylating agents associated with the risk of occurrence of t-MN.
| Monofunctional agents | DNA adduct | DNA repair | ||
|---|---|---|---|---|
| Dacarbazine | Procarbazine | Temozolomide | ||
 |
 |
 |
O6–meG → | MGMT, MMR |
| DSBs → | FANC pathway (HR) | |||
| 3–meA; 7-meG → | BER | |||
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