Tab. 3.
The transdermal permeation parameters of progesterone obtained after non-occlusive (open) application of various formulations.
| Formulation | Open application without skin pretreatment | Open application after skin pretreatment with 40% ethanol | ||
|---|---|---|---|---|
| Flux (μg cm−2 h−1) | Lag time (h) | Flux (μg cm−2 h−1) | Lag time (h) | |
| EFME | 2.36 (0.08) | 3.41 (0.64) | 2.85 (0.20) | 1.79 (0.12) |
|
| ||||
| Open application of fully saturated formulation | Open application of formulation containing drug at 2 degrees of saturation (DS)* | |||
|
|
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| Flux (μg cm−2 h−1) | Lag time (h) | Flux (μg cm−2 h−1) | Lag time (h) | |
| 40% EME | 7.25 (2.01) | 0.28 (0.22) | 5.85 (0.12) | 0.81 (0.19) |
Values between brackets are SEM, n = 3.
*
DS of 2 was prepared by dissolving 43.4 mg/ml of drug in 40% EME. Open application of this formulation will create ME with 2 DS after evaporation of ethanol.