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. 2012 Aug 13;11:54. doi: 10.1186/1476-4598-11-54

Figure 4.

Figure 4

IBP is p53 dependently suppressed in response to DNA damaging agents. The expression of IBP was tested with Western analysis. (A) MCF-7 and ZR-75-1 which are human breast cancer cells with wild type p53 expression were treated with cisplatin for 24 h. (B) MCF-7 and ZR-75-1 cells were treated with doxorubicin for 8 h. (C) HCT116 p53+/+ cells and HCT116 p53−/− cells were treated with cisplatin for 24 h. (D) p53-RNAi MCF-7 cells were treated with cisplatin for different concentrations. Left was the RNAi effect of p53 in MCF-7 cells. GAPDH was used as a control.