Table 2.
Adjustedahazard ratio (95% Confidence interval) of all-Cause and cardiovascular disease mortality, by eGFR categories among 16,010 participants of NHANES III (1988–1994) with follow-up till December 31, 2006
| |
|
Categories of eGFR (ml/min/1.73 m2) |
||||
|---|---|---|---|---|---|---|
| |
|
≥ 120 |
90-119 |
60-89 |
30-59 |
< 30 |
| All-Cause Mortality | ||||||
|
EGFRCKD-EPI |
Participants, N |
3,889 |
7,151 |
3,947 |
956 |
67 |
| |
Deaths, N |
179 |
921 |
1,686 |
775 |
59 |
| |
HR |
2.05 |
Reference |
0.97 |
1.39 |
1.38 |
| |
(95% CI) |
(1.55-2.71) |
|
(0.86-1.10) |
(1.17-1.65) |
(0.88-2.16) |
|
EGFRMDRD |
Participants, N |
2,729 |
6,604 |
5,606 |
1,015 |
56 |
| |
Deaths, N |
228 |
805 |
1,788 |
750 |
49 |
| |
HR |
1.70 |
Reference |
0.94 |
1.31 |
1.96 |
| |
(95% CI) |
(1.36-2.14) |
|
(0.84-1.05) |
(1.11-1.56) |
(1.11-3.44) |
|
CVD Mortality |
|
|
|
|
|
|
|
EGFRCKD-EPI |
Participants, N |
3,889 |
7,151 |
3,947 |
956 |
67 |
| |
Deaths, N |
41 |
303 |
755 |
412 |
29 |
| |
HR |
2.70 |
Reference |
1.05 |
1.49 |
1.64 |
| |
(95% CI) |
(1.54-4.73) |
|
(0.87-1.26) |
(1.16-1.92) |
(1.02-2.65) |
|
EGFRMDRD |
Participants, N |
2,729 |
6,604 |
5,606 |
1,015 |
56 |
| |
Deaths, N |
64 |
278 |
774 |
401 |
23 |
| |
HR |
1.53 |
Reference |
0.95 |
1.32 |
2.17 |
| (95% CI) | (0.96-2.45) | (0.79-1.13) | (0.99-1.78) | (1.18-3.98) | ||
Abbreviations: eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease Study; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; CVD, Cardiovascular Disease.
a Adjusted for age, sex, race/ethnicity, prior CVD, diabetes, smoking, systolic and diastolic blood pressure, use of antihypertensive medications, body mass index, cholesterol, C-reactive protein category and albumin-to-creatinine ratio category.