Table 3.
Reclassification and adjusted hazard ratiosaof all-cause and cardiovascular disease mortality by eGFR categories determined using the MDRD and the CKD-EPI study equation: NHANES III (1988–1994) - follow-up till December 31, 2006
| EGFRCKD-EPICategories | |||||
|---|---|---|---|---|---|
|
EGFRMDRDCategories |
>120 |
90-119 |
60-89 |
30-59 |
<30 |
|
>120 |
|
|
|
|
|
| Reclassified, N b (%)c |
2,416 (88.3) |
312 (11.7) |
|
|
|
|
All-Cause Mortality |
|
|
|
|
|
| Deaths, N b |
126 |
101 |
|
|
|
| HR (95% CI) |
REFERENCE |
0.57 (0.26-1.26) |
|
|
|
|
CVD Mortality |
|
|
|
|
|
| Deaths b |
28 |
36 |
|
|
|
| HR (95% CI) |
REFERENCE |
0.37 (0.15-0.94) |
|
|
|
|
90-119 |
|
|
|
|
|
| Reclassified, N b (%)c |
1,473 (20.2) |
4,969 (78.4) |
162 (1.4) |
|
|
|
All-Cause Mortality |
|
|
|
|
|
| Deaths, N b |
53 |
604 |
148 |
|
|
| HR (95% CI) |
1.42 (0.85-2.37) |
REFERENCE |
1.39 (0.94-2.07) |
|
|
|
CVD Mortality |
|
|
|
|
|
| Deaths b |
13 |
193 |
72 |
|
|
| HR (95% CI) |
2.95 (1.03-8.42) |
REFERENCE |
1.79 (0.94-3.39) |
|
|
|
60-89 |
|
|
|
|
|
| Reclassified, N b (%)c |
|
1,870 (42.9) |
3,664 (56.6) |
72 (0.5) |
|
|
All-Cause Mortality |
|
|
|
|
|
| Deaths, N b |
|
216 |
1,506 |
66 |
|
| HR (95% CI) |
|
1.13 (0.91-1.42) |
REFERENCE |
1.31 (1.01-1.69) |
|
|
CVD Mortality |
|
|
|
|
|
| Deaths b |
|
74 |
669 |
31 |
|
| HR (95% CI) |
|
1.02 (0.69-1.50) |
REFERENCE |
1.42 (1.01-1.99) |
|
|
30-59 |
|
|
|
|
|
| Reclassified, N b (%)c |
|
|
120 (19.4) |
883 (79.5) |
12 (1.1) d |
|
All-Cause Mortality |
|
|
|
|
|
| Deaths, N b |
|
|
31 |
708 |
11 |
| HR (95% CI) |
|
|
0.53 (0.34-0.84) |
REFERENCE |
N/A |
|
CVD Mortality |
|
|
|
|
|
| Deaths b |
|
|
14 |
381 |
6 |
| HR (95% CI) | 0.51(0.27-0.96) | REFERENCE | N/A | ||
Abbreviations: eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease Study; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; HR, Hazard Rate; CVD, cardiovascular disease; N/A, not applicable.
a Adjusted for age, sex, race/ethnicity, prior CVD, systolic or diastolic blood pressure, use of antihypertensive medications, diabetes status, smoking status, body mass index, cholesterol, CRP category and albumin-to-creatinine ratio category.
b Numbers represent crude (un-weighted) participant number.
c Percent represents the population percent representative of the non-institutionalized US population; total may not equal 100% due to rounding.
d HR not presented as there are less than 30 people in the cell.