Table 4.
Net reclassification improvement by the CKD-EPI equation among participants with eGFR <120 ml/min/1.73 m2by both equations stratified by age, sex and race
| |
Reclassification, number (Population %)a |
Deaths, |
NRI |
|
|---|---|---|---|---|
| All-cause (CVD) | All-cause | CVD | ||
|
Overall |
11,808 (24.1%) |
3,339 (1,463) |
0.2073*** |
0.2216*** |
|
By Age Categories | ||||
| 17-44 |
4,822 (30.3%) |
208 (58) |
0.0216 |
−0.0883 |
| 45-64 |
3,491 (21.8%) |
715 (258) |
−0.0146 |
−0.0006 |
| ≥65 |
3,495 (11.4%) |
2,416 (1,147) |
0.1362*** |
0.0943*** |
|
By Sex | ||||
| Male |
5,839 (22.1%) |
1,844 (796) |
0.2077*** |
0.2277*** |
| Females |
5,969 (26.0%) |
1,495 (667) |
0.2063*** |
0.2157*** |
|
By Race/Ethnicity | ||||
| NH Whites |
5,736 (25.7%) |
1,957 (903) |
0.2258*** |
0.2368*** |
| NH Blacks |
2,701 (12.8%) |
710 (290) |
0.1245*** |
0.1229*** |
| Mex-Am |
2,868 (20.2%) |
594 (239) |
0.0648** |
0.0682* |
| Others | 503 (20.2%) | 78 (31) | 0.1427* | 0.2559*** b |
Abbreviations: eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease Study; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; NRI, Net Reclassification Improvement; NH, Non-Hispanic; Mex-Am, Mexican-American.
a Reclassification to a different eGFR category by CKD-EPI equation. Number represents the number of participants; Population % is representative of the non-institutionalized US population.
b NRI estimates less precise as there are <50 events in this cell.
* p < 0.05; ** p < 0.01; *** p < 0.001.