Table 1.
Baseline data for used AC cohorts
| Illumina | DCC | GSE10072 | GSE12667 | Beer et al. | GSE32863 | GSE11969 | |
|---|---|---|---|---|---|---|---|
| Data set type |
Original cohort |
External |
External |
External |
External |
External |
External |
| Microarray platform |
Illumina HT12 |
Affymetrix U133A |
Affymetrix U133A |
Affymetrix U133 2plus |
Affymetrix HU6800 |
Illumina WG6 |
Agilent |
| Number of AC cases* |
39*** |
349 |
58 |
51 |
81 |
58 |
90 |
| Stage IA/IB/IIA/IIB/IIIA |
10/18/4/3/2 |
84/133/16/64/45 |
5/17/3/18/9 |
2/9/0/2/2 |
NA |
16/18/9/2/12 |
28/24/4/9/20 |
| Median age (years) |
69 (36–83) |
65 (35–87) |
67.5 (45–81) |
NA |
64 (41–85) |
70 (39–86) |
62 (32–84) |
| Female/Male |
21/18 |
187/162 |
23/35 |
24/27 |
47/34 |
45/13 |
43/47 |
| Never-smokers/Smokers |
10/27 |
49/300 |
16/42 |
8/43 |
9/72 |
29/29 |
45/45 |
| Never/Current/Former smokers |
10/13/14 |
49/32/268 |
16/24/18 |
8/18/25 |
9/NA/NA |
29/29/0 |
45/NA/NA |
| Percentage never-smokers |
27% |
14% |
28% |
16% |
11% |
50% |
50% |
| Never-smokers (Female/Male) |
6/4 |
40/9 |
13/3 |
6/2 |
9/0 |
23/6 |
35/10 |
|
EGFR mutation/wt |
4/35 |
NA |
NA |
NA |
NA |
NA |
32/58 |
|
KRAS mutation/wt |
12/27 |
NA |
NA |
NA |
36/44 |
NA |
10/80 |
| P53 +/wt |
NA |
NA |
NA |
NA |
16/64 |
NA |
29/61 |
| Mean follow-up OS (years)** | 6.2 (0–15.5) | 4.3 (0–17) | NA | NA | 3 (0.1–9.2) | NA | 5.5 (0.5–9) |
* Number of cases with smoking history.
** OS: Overall survival.
***: Two cases are not annotated for smoking.