Table 2.
Association of AC1/AC2 subgroups in external AC data sets with smoking history
| Data set | Nbr NS/smokers* | Nbr NS/CS/FS* | Nbr NS classified as AC1 | % smokers classified as AC1 (All/CS/FS) | Fisher’s exact test P-value ** |
|---|---|---|---|---|---|
| DCC |
49/300 |
49/32/268 |
45 (92%) |
53/31/55 |
4 × 10−8/0.01 |
|
GSE10072 |
16/42 |
16/24/18 |
15 (94%) |
55/46/67 |
0.005/0.22 |
|
GSE12667 |
8/43 |
8/18/25 |
8 (100%) |
49/33/60 |
0.007/0.12 |
| Beer et al. |
9/72 |
9/NA/NA |
8 (89%) |
53/NA/NA |
0.07/NA |
|
GSE11969 |
45/45 |
45/NA/NA |
37 (82%) |
58/NA/NA |
0.02/NA |
| GSE32863 | 29/29 | 29/29/0 | 23 (79%) | 38/38/NA | 0.003/NA |
* NS: never-smoker, CS: current smoker, FS: former smoker.
** Calculated from a 2×2 contingency table summarizing number of never-smokers and smokers for each AC subgroup (first p-value), or number of CS and FS for each AC subgroup (second p-value).