Table 4.
Association of the AC1/AC2 and DCC signature with smoking history in normal airway epithelial samples, and adjacent lung tissue
| Data set | Number NS/S/CS/FS* | Number NS classified as AC1 | % S/CS/FS classified as AC1 | P-value AC1/AC2 classification** | Number correctly identified NS by DCC signature*** | % S/CS/FS classified as never-smokers by DCC signature | P-value DCC classification** |
|---|---|---|---|---|---|---|---|
|
GSE19027 |
8/44/24/20 |
7 (88%) |
55/54/55 |
0.12 |
8 (100%) |
45/21/75 |
0.005 |
|
GSE7895 |
21/83/52/31 |
16 (76%) |
37/23/61 |
0.003 |
16 (76%) |
42/40/45 |
0.007 |
|
GSE19667 |
48/73/NA/NA |
38 (79%) |
33/NA/NA |
8 × 10−7 |
31 (65%) |
33/NA/NA |
0.0008 |
|
GSE11952 |
38/45/45/0 |
29 (76%) |
29/29/0 |
2 × 10−5 |
21 (55%) |
38/38/0 |
0.13 |
|
GSE32863A |
30/28/28/0 |
23 (77%) |
39/39/0 |
0.007 |
24 (80%) |
39/39/0 |
0.003 |
| GSE10072A | 15/34/16/18 | 12 (80%) | 44/38/50 | 0.03 | 13 (87%) | 44/38/50 | 0.01 |
* NS: never-smoker, S: smoker, CS: current smoker, FS: former smoker.
** Fisher’s exact P-value calculated from a 2×2 contingency table summarizing number of never-smokers and smokers for each classification group.
*** NS classified as never-smoker by the classifier.
A Adjacent normal lung tissue data set.