Table 2.
Correlation between cancer biomarkers and bone metastasis
| Biomarkers | Bone metastasis |
Non-bone metastasis |
P value |
|
|---|---|---|---|---|
| n (%) | n (%) | |||
|
OPN |
+ |
40 (93.0) |
48 (77.4) |
0.033 |
| |
- |
3 (7.0) |
14 (22.6) |
|
| c-Src |
+ |
45 (100) |
56 (93.3) |
0.133 |
| |
- |
0 (0) |
4 (6.7) |
|
| MMP2 |
+ |
38 (88.4) |
47 (75.8) |
0.107 |
| |
- |
5 (11.6) |
15 (24.2) |
|
|
CXCR4 |
+ |
40 (90.9) |
32 (52.5) |
0.000 |
| |
- |
4 (9.1) |
29 (47.5) |
|
|
BSP |
+ |
44 (97.8) |
49 (81.7) |
0.012 |
| |
- |
1 (2.2) |
11 (18.3) |
|
| PTHrP |
+ |
42 (68.8) |
28 (63.4) |
0.647 |
| |
- |
19 (31.2) |
16 (36.6) |
|
| IGF-1R |
+ |
58 (95.1) |
39 (88.6) |
0.383 |
| |
- |
3 (4.9) |
5 (21.4) |
|
|
BMP4 |
+ |
22 (48.9) |
51 (85) |
0.000 |
| |
- |
23 (51.1) |
9 (15.0) |
|
| PI3K |
+ |
43 (95.6) |
55 (91.7) |
0.696 |
| |
- |
2 (4.4) |
5 (8.3) |
|
| NFκB |
+ |
58 (95.1) |
39 (88.6) |
0.383 |
| - | 3 (4.9) | 5 (21.4) | ||