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. Author manuscript; available in PMC: 2012 Sep 20.
Published in final edited form as: Cancer Metastasis Rev. 2011 Dec;30(3-4):419–435. doi: 10.1007/s10555-011-9300-5

Fig. 5.

Fig. 5

ARE-binding proteins mediating posttranscriptional the regulation of COX-2. COX-2 expression is tightly regulated at the posttranscriptional level by RNA-binding proteins that promote mRNA stability (HuR, CUGBP2, and RBM3), mRNA decay (TTP), and translational inhibition (TIA-1 and CUGBP2) through their binding of the COX-2 AU-rich element (ARE)