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. 2012 Sep 20;7(9):e45824. doi: 10.1371/journal.pone.0045824

Figure 4. Analysis of the transcriptional activity of fragments of intron 1 of the human GCK gene.

Figure 4

A. Activity of large fragments spanning most of intron 1. B Activates of subfragments of intronic fragment Int-3 (I-3). Schematics on the left indicate the relative positions of fragments of intron 1 inserted downstream of a luciferase reporter gene in the pGK-1049Luc reporter plasmid. See Fig. S1 for the locations of genomic fragments within the gene. Reporter gene activities of the constructs in human L-02 and HepG2 cells are shown on the right. Data are the Mean ± SD of three independent experiments. Asterisk (*) indicates constructs that have significantly different activity than the −1049 construct (P<0.05).