Table 2.
Frequencies and distribution of genetic abnormalities by CD25 expression in the subgroup with E1900 patients with mutational analysis
| Mutations | CD25NEG (n = 321), no. (%) | CD25POS (n = 75), no. (%) | P |
|---|---|---|---|
| DNMT3A | 55 (18) | 33 (44) | < .001 |
| DNMT3A R882 | 36 (12) | 27 (36) | < .001 |
| DNMT3A other | 21 (7) | 6 (8) | .801 |
| IDH1 or IDH2 | 51 (16) | 5 (7) | .043 |
| TET2 | 28 (9) | 5 (7) | .695 |
| FLT3-ITD | 63 (20) | 57 (76) | < .001 |
| FLT3-TKD mutated | 23 (7) | 4 (5) | .79 |
| NPM1 | 83 (26) | 35 (46) | .001 |
| PHF6 | 7 (2) | 2 (3) | .688 |
| KIT | 22 (7) | 1 (1) | .096 |
| CEBPa | 32 (10) | 2 (3) | .040 |
| WT1 | 21 (7) | 9 (12) | .149 |
| KRAS | 6 (2) | 2 (3) | .654 |
| NRAS | 37 (12) | 3 (4) | .055 |
| TP53 | 6 (2) | 2 (3) | .654 |
| PTEN | 4 (2) | 2 (3) | .326 |
| RUNX1 | 13 (4) | 7 (9) | .090 |
| CBF | 42 (13) | 1 (1) | .002 |
| del(5q) | 11 (3) | 1 (1) | .476 |
| EVI1pos* | 7 (2) | 1 (1) | 1.000 |
| MLL-PTD | 11 (3) | 8 (11) | .016 |
| Split MLL* | 25 (8) | 0 (0) | .007 |
| del(7q) of monosomy 7† | 8 (3) | 3 (1) | 1.000 |
| Trisomy 8† | 13 (4) | 6 (8) | .227 |
| Complex karyotype‡ | 29 (9) | 2 (3) | .091 |
CBF indicates core-binding-factor leukemias (carrying transcripts AML1/ETO or CBFβ/MYH11) that were detected by OCR and FISH; ITD, internal tandem duplication; PTD, partial tandem duplication; TKD, tyrosine kinase domain.
EVI1 and chromosome translocation resulting into a split of the MLL gene (split MLL) were assessed by FISH.
del(7q)/monosomy 7 and trisomy 8 were assessed by standard cytogenetics or FISH.
‡
Complex karyotypes were defined as ≥ 3 clonal cytogenetic aberrations.