Table 1. Histological characterization of 3-methyl-cholanthrene-induced sarcomas.
| Genotype | Histotype1 | Local Infiltration2 | Necrosis3 | Survival (Days) | p534 | p53 Localization |
| WT | Spindle + Round | 0 | 1 | 139 | ND | ND |
| WT | Spindle | 1 | 0 | 120 | 0 | |
| WT | Spindle | 1 | 0 | 150 | 2 | Nucleo + Cytoplasm |
| Stm+/− | Spindle + Pleomorphic | 0 | 2 | 138 | 2 | Cytoplasm |
| Stm+/− | Round | 1 | 0 | 139 | 3 | Nucleo + Cytoplasm |
| Stm+/− | Spindle | 2 | 0 | 120 | 0 | |
| Stm KO | Spindle | 1 | 2 | 127 | 1 | Cytoplasm |
| Stm KO | Spindle + Round | 0 | 0 | 150 | 3 | Nucleo +Cytoplasm |
1
Tumors were classified according to their morphology as spindle, pleomorphic or round cell sarcomas. In some cases, multiple morphologic phenotypes were present in the same tumor.
2
Local Infiltration was rated as follows: 0 = no tumor infiltration; 1 = minimal tumor infiltration in the surrounding muscle; 2 = massive tumor infiltration.
3
Necrosis was rated as follows: 0 = no necrosis; 1 = minimal areas of necrosis; 2 = large areas of necrosis.
4
p53 staining was rated as follows: 0 = no staining; 1 = faint staining in less than 50% of the cells; 2 = strong staining in less than 50% of the cells; 3 = strong staining in more than 50% of the cells. ND = not done.