Figure 2.

Increased PAI-1 concentration is demonstrated by the intensity of brown immunohistochemical staining of specimens of diseased coronary arteries from representative patients with type 2 diabetes (top row) when compared with similar specimens from representative patients without diabetes (bottom row). Negative controls, obtained with the use of normal murine IgG instead of primary antibody against PAI-1, showed no detectable staining (data not shown). Magnification ×100. The figure is adapted with permission from Sobel et al. (21). (A high-quality digital representation of this figure is available in the online issue.)