A: Relevance of the presence and severity of PAD for the cumulative probability of a first major limb amputation. To avoid complexity, PAD not classified because of medial arterial calcification is not shown (n = 8; only 1 event of first major limb amputation). The highest curve represents no PAD, the second curve represents mild PAD, the third curve represents moderate PAD, and the lowest curve represents severe PAD. B: Relevance of the presence or absence of PAD, advanced renal disease, or both combined for the cumulative probability of death. The highest curve represents no PAD and no renal disease, the second curve represents renal disease and no PAD, the third curve represents PAD and no renal disease, and the lowest curve represents PAD and renal disease.