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. 2012 Sep 20;7(9):e45171. doi: 10.1371/journal.pone.0045171

Figure 3. Increased proportion of splenic pDCs in MCMV-infected WT male mice.

Figure 3

WT and TLR9−/− male and female mice were left uninfected or infected i.p. with 1×105 PFU of MCMV and spleens were harvested 36 h later. Erythrocyte-depleted splenocytes were analyzed by flow cytometry for the expression of B220, CD11c and Ly6C. Upon MCMV-infection the percentage of pDCs (B220+Ly6ChiCD11clo) is increased in all four mouse groups, while the percentage of cDCs (B220−Ly6C−CD11chi) is slightly decreased. Interestingly, upon MCMV infection WT male mice showed statistically significant increased percentage of pDCs compared to WT females. Percentages on pDCs and cDCs are presented as mean ± SEM *p<0.05. The data are representatives of 3 mice per group and of 3 independent experiments.