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. 2012 Sep 13;61(10):2414–2423. doi: 10.2337/db11-0915

FIG. 7.

FIG. 7.

Global but not BAT-specific loss of MSTN signaling reduces blood glucose and food intake in A-ZIP mice. A: Blood glucose of WT mice, A-ZIP mice, double-mutant Mstn heterozygous (het) A-ZIP mice, and double-mutant A-ZIP, Mstn null (KO) mice. B: Daily food intake of Mstn heterozygous mice, A-ZIP mice, double-mutant Mstn heterozygous, A-ZIP mice, and double-mutant A-ZIP, Mstn null mice (n = 4–7 for each genotype at age 12 weeks). Blood glucose (C) and daily food intake (D) in WT mice, mice expressing a fat-specific DN Acvr2b receptor transgene (Fat-DN), A-ZIP mice, and double-transgenic A-ZIP, Fat-DN mice measured at age 12 weeks (n = 5–8 for each genotype). Results are presented as mean ± SEM. **P < 0.01, ***P < 0.001.