Skip to main content
. 2012 Sep 13;61(10):2597–2608. doi: 10.2337/db11-1349

FIG. 3.

FIG. 3.

Overexpression of hnRNP F attenuates systemic hypertension in Akita Tg mice. A: Longitudinal changes in mean SBP in male WT control (□), hnRNP F-Tg (△), Akita (▲), and Akita hnRNP F-Tg mice (▼). The mice were trained in the procedure for at least 15–20 min per day for 5 days before the first SBP measurements. B: Cross-sectional analysis of SBP (measured two to three times per animal per week in the morning without fasting, week 20). Serum Agt levels (C), serum Ang II levels (D), urinary Agt levels (E), urinary Ang II levels (F), Agt levels in whole-kidney extracts (G), and Ang II levels in whole-kidney extracts (H) in WT controls, hnRNP F-Tg, Akita, and Akita hnRNP F-Tg mice. Serum and urinary Agt were assayed by specific enzyme-linked immunosorbent assay (ELISA), and urinary Agt levels were normalized with urinary creatinine levels. Serum and urinary Ang II were extracted, assayed by specific ELISA, and normalized with urinary creatinine levels. Agt and Ang II levels in whole-kidney extracts were assayed by respective ELISA for Agt and Ang II. All data are expressed as means ± SEM; N = 6. WT and hnRNP F-Tg mice, empty bars; Akita and Akita hnRNP F-Tg mice, filled bars. *P < 0.05; **P < 0.01; ***P < 0.005.