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. 2012 Sep 13;61(10):2597–2608. doi: 10.2337/db11-1349

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© 2012 by the American Diabetes Association.

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FIG. 4. — Overexpression of hnRNP F attenuates renal hypertrophy in Akita Tg mice. A: Kidney size. B: KW/BW ratio. C: WB of p27^kip1 protein expression in RPTs of WT controls, hnRNP F-Tg, Akita, and Akita hnRNP F-Tg mice. The relative densities of the p27^Kip1 band were normalized with the β-actin band. p27^Kip1 level in WT control mouse RPTs was considered as the control (100%). D: Periodic acid Schiff staining of mouse kidneys: WT control mouse (a), hnRNP F-Tg mouse (b), Akita mouse (c), and Akita hnRNP F-Tg mouse (d) at week 20. Original magnification ×600. Mean glomerular volume (E), mean RPTC volume (F), and mean tubular luminal area (G) of WT control mice, hnRNP F-Tg mice, Akita mice, and Akita hnRNP F-Tg mice at week 20. **P < 0.01; ***P < 0.005. (A high-quality digital representation of this figure is available in the online issue.)