Table 2. Regions Showing Significantly changed ALFF value in ALS Patients.

	Anatomic regions	Brodmann area	Coordinates of peak voxel (X, Y, Z) a	Maximum T score	Number of voxels	P-corrected with FWE
WithoutGMcorrection	ALS>control
	Frontal_Mid_L	46	−29 32 32	5.58	52	0.015
	ALS<control
	Postcentral_R	3	49 −26 47	−4.85	45	0.03
	Fusifrom	37	27 −51 −11	−5	60	0.008
	Occipital_Inf	18/19	−32 −82 −11	−6.52	642	<0.001
WithGMcorrection	ALS>control
	Frontal_Inf_R	11	40 33 −7	5.43	37	0.012
	Frontal_Mid_L	46	−29 32 32	6.43	84	<0.001
	ALS<control
	Postcentral_R	3	49 −26 47	−4.96	36	0.013
	Fusifrom	37	27 −51 −11	−5.08	50	0.002
	Occipital_Inf	18/19	−32 −82 −11	−6.28	522	<0.001

^aX, Y and Z are location of peak voxel in the Talairach–Tournoux coordinate;

The statistical threshold was set at voxel-wise t>3.32 (P<0.001) and cluster level of p<0.05 corrected by FWE (family-wise error).