Table 2. Regions Showing Significantly changed ALFF value in ALS Patients.
Anatomic regions | Brodmann area | Coordinates of peak voxel (X, Y, Z) a | Maximum T score | Number of voxels | P-corrected with FWE | |
WithoutGMcorrection | ALS>control | |||||
Frontal_Mid_L | 46 | −29 32 32 | 5.58 | 52 | 0.015 | |
ALS<control | ||||||
Postcentral_R | 3 | 49 −26 47 | −4.85 | 45 | 0.03 | |
Fusifrom | 37 | 27 −51 −11 | −5 | 60 | 0.008 | |
Occipital_Inf | 18/19 | −32 −82 −11 | −6.52 | 642 | <0.001 | |
WithGMcorrection | ALS>control | |||||
Frontal_Inf_R | 11 | 40 33 −7 | 5.43 | 37 | 0.012 | |
Frontal_Mid_L | 46 | −29 32 32 | 6.43 | 84 | <0.001 | |
ALS<control | ||||||
Postcentral_R | 3 | 49 −26 47 | −4.96 | 36 | 0.013 | |
Fusifrom | 37 | 27 −51 −11 | −5.08 | 50 | 0.002 | |
Occipital_Inf | 18/19 | −32 −82 −11 | −6.28 | 522 | <0.001 |
X, Y and Z are location of peak voxel in the Talairach–Tournoux coordinate;
The statistical threshold was set at voxel-wise t>3.32 (P<0.001) and cluster level of p<0.05 corrected by FWE (family-wise error).