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. 2012 Sep 20;8(9):e1002926. doi: 10.1371/journal.pgen.1002926

Figure 6. The effect of Cadm1 expression on tumor and metastasis in CD8+ T cell depleted mice.

Figure 6

Orthotopic injections of control and Cadm1-expressing Mvt-1 cells into immune-competent FVB mice that were treated with IgG or anti-CD8 resulted in (a) >90% depletion of CD8+ T cells. (b) No significant differences were observed in tumor burden between control and Cadm1 expressing within the same antibody treatment group, though a significant increase was observed in control Mvt-1 cells upon anti-CD8 treatment. (c) Total pulmonary metastases showed significant suppression in Mvt-1/Cadm1 in both control and anti-CD8 treatment groups. (d) Metastases normalized by matched primary tumor mass showed highly significant Cadm1-mediated metastasis suppression in the control IgG treatment group but was not significant in the anti-CD8 group (median +/− interquartile range; n = 10 mice per group). ELISPOT plate (e) and quantitative representation (f) of interferon-γ secreting T cells (mean +/− SEM). (N.S., not significant; * defined as p<0.05; ** defined as p<0.01; *** defined as p<0.001, **** defined as p<0.0001).