Figure 4. Models of the Tsr trimer of dimers.

A Initial trimer-of-dimers model based on a structure exhibiting the modal bending angle derived from simulations of the individual dimers, with the constituent dimers packed together into the trimer using crystal contacts in the coiled coil domain (1QU7). B “Closed” trimer model generated after 0.5 µs MD with restraints on crystal contacts. C Cryoelectron tomography image of the trimer taken from Khursigara et al [7].