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. 2012 Sep 20;8(9):e1002645. doi: 10.1371/journal.pcbi.1002645

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© 2012 Lewis et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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We show the results of inferring interactions from S. cerevisiae (SC), C. elegans (CE), D. melanogaster (DM), H. sapiens (HS), S, Pombe (SP), and M. musculus (MM) to the first four of those species. (A) Number of correct interolog inferences across species, for different blastp -value cut-offs. (B) Fraction of all inferences that are observed in the interactions of the target species, . (C) The likelihood ratio that an inference is correct. This indicates how much better it is to use the inferences than to select random pairs of proteins in the target species that have homologs in the source species interactome. (A) and (B) together indicate that it is only at lax -values that one makes significant numbers of correct inferences, but this is a very small fraction of the total number of inferences made at these -values. The S. cerevisiae data-set coverage is significantly higher than that of other species, so one obtains larger values for inferences to S. cerevisiae.

Inline graphic — We show the results of inferring interactions from S. cerevisiae (SC), C. elegans (CE), D. melanogaster (DM), H. sapiens (HS), S, Pombe (SP), and M. musculus (MM) to the first four of those species. (A) Number of correct interolog inferences across species, for different blastp -value cut-offs. (B) Fraction of all inferences that are observed in the interactions of the target species, . (C) The likelihood ratio that an inference is correct. This indicates how much better it is to use the inferences than to select random pairs of proteins in the target species that have homologs in the source species interactome. (A) and (B) together indicate that it is only at lax -values that one makes significant numbers of correct inferences, but this is a very small fraction of the total number of inferences made at these -values. The S. cerevisiae data-set coverage is significantly higher than that of other species, so one obtains larger values for inferences to S. cerevisiae.