Table 4. Top LOPAC1280 Hits.
| Sample Name | Protein Binding Preference | AGP 1,536-wellScreen IC50 [µM]1 | AGP 96-wellIC50 [µM] | HSA 1,536-wellScreen IC50 [µM]1 | HSA 96-wellIC50 [µM] |
| Linopirdine | AGP | 35.5 | 21.7 | >151 | ND |
| Mifepristone | AGP | 6.31 | 2.51 | >151 | ND |
| PK 11195 | AGP | 22.4 | 23.9 | >151 | ND |
| GW2974 | HSA | >144 | ND | 7.94 | 4.65 |
| Prazosin | HSA | 50.1 | 17.5 | 11.2 | 5.87 |
| 4-Amino-1,8-naphthalimide | AGP/HSA | 11.2 | 832 | 7.94 | 37.0 |
| Aminopterin | AGP/HSA | 56.2 | 306 | 8.91 | 22.0 |
| K 185 | AGP/HSA | 20.0 | 10.5 | 56.2 | 83.2 |
| L-765,314 | AGP/HSA | 14.1 | 2.03 | 70.8 | 5.21 |
| YC-1 | AGP/HSA | 5.62 | 4.83 | 44.7 | 5.07 |
| Venlafaxine | None | >144 | >1,000 | >151 | >1,000 |
1
Top compound concentrations of 144 or 151 µM for the AGP and HSA assays, respectively.