Fig. 4.

Effect of intracerebroventricular (i.c.v.) injection of d-lys³-GHRP-6 on the inhibitory action of ghrelin on hyperalgesia (a) and paw edema (b) induced by i.pl. carrageenan. d-Lys³-GHRP-6 was injected 5 min before ghrelin and 135 min after carrageenan. Ghrelin was injected i.c.v. 5 min before i.pl. carrageenan. Paw pressure threshold and paw volume were measured prior to carrageenan (basal) and at various times after carrageenan. Each value is the mean ± SEM of 6–8 rats. **P < 0.001 versus basal; ^•• P < 0.01, ^••• P < 0.001 versus saline; ^# P < 0.05 versus ghrelin