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Effect of intracerebroventricular (i.c.v.) injection of desacyl-ghrelin (DAG) on hyperalgesia (a) and paw edema (b) induced by carrageenan. DAG was administered 5 min before i.pl. carrageenan. Paw pressure threshold and paw volume were measured prior to carrageenan (basal) and at various times after carrageenan. Each value is the mean ± SEM of 10–12 rats. *P < 0.05, **P < 0.001 versus basal; • P < 0.05, •• P < 0.01, ••• P < 0.001 versus saline
