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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Lancet Oncol. 2012 Aug 15;13(9):906–915. doi: 10.1016/S1470-2045(12)70274-7

Figure 4C. Cumulative osteonecrosis incidence by RER regimen Age ≥10 years (N=823).

Figure 4C

RER = rapid early response

CD = continuous dexamethasone

AWD = alternate-week dexamethasone

Rx = therapy

IM = interim maintenance

DI = delayed intensification

RHR = relative hazard ratio

Cumulative osteonecrosis incidence by RER regimen in patients age ≥16 years:

All A: 38·1±14·4%, B: 16·5±9·1%, C: 37·3±15·6%, D: 6·8±5·7% (p=0·0028)

Females A: 57·6±18·6%, B: 33·9±17·2%, C: 31·8±19·2%, D: 5·6±7·0% (p=0·035)

Males A: 28·3±19·1%, B: 8·2±8·8%, C: 38·7±22·0%, D: 7·7±9·1%, 2/27 (p=0·011)