RER = rapid early response
CD = continuous dexamethasone
AWD = alternate-week dexamethasone
Rx = therapy
IM = interim maintenance
DI = delayed intensification
RHR = relative hazard ratio
Cumulative osteonecrosis incidence by RER regimen in patients age ≥16 years:
All A: 38·1±14·4%, B: 16·5±9·1%, C: 37·3±15·6%, D: 6·8±5·7% (p=0·0028)
Females A: 57·6±18·6%, B: 33·9±17·2%, C: 31·8±19·2%, D: 5·6±7·0% (p=0·035)
Males A: 28·3±19·1%, B: 8·2±8·8%, C: 38·7±22·0%, D: 7·7±9·1%, 2/27 (p=0·011)