Figure 9. Dependence of effect of airway smooth muscle integrin α₉β₁ on PIP5K1γ.

(A and B) Airway narrowing in lung slices treated with control antibody (A) or blocking antibody (B) and infected by adenovirus expressing full-length, truncated, or kinase-dead PIP5K1γ. (C) Airway narrowing in lung slices treated with control antibody or blocking antibody and infected by adenovirus expressing shRNA targeting mouse PIP5K1γ. (D) Decreased PIP5K1γ expression in mouse lung slices after infection with adenovirus expressing shRNA targeting PIP5K1γ. Mouse lung slices were incubated with shRNA-expressing adenovirus for 0, 1, 2, or 3 days. Data (mean ± SEM) represent 2 independent experiments with similar results. *P < 0.01.