Table 2.

Common genetic variations in Notch Pathway genes

Gene	Variant	Function	Rate	Ref.
NOTCH1	Mutation	Activation (T-ALL)	60%	[54]
NOTCH1	Mutation	Response to GSI and prognosis (NSCLC)	12%	[55]
NOTCH2	Mutation	Unknown (Breast Cancer)	2.1%	[57]
NOTCH3	Mutation	Unknown(Colorectal Cancer)	2%	[57]
NOTCH3	Amplification	Response to GSI (Ovarian Cancer)	19.5%	[56]
NOTCH2	SNP	Increased cancer risk (Breast Cancer)	16.8%	[58]
HEY1	SNP	Response to p53 activators	1%	[59]

We selected both single nucleotide polymorphisms (SNP) and somatic alterations (gene amplifications, mutations) affecting cancer cell behavior. Rate refers to mutation rate in cancer samples, or minor allele frequency in Caucasians (SNP). T-ALL, T-cell acute lymphoid leukemia; NSCLC, non-small cell lung cancer; GSI, γ-secretase inhibitor.