Table 2. Involvement of miRNA in urological cancers.
| Role | microRNA | Validated targets | References |
|---|---|---|---|
| OncomiRs | miR-17-92 | PTEN, BIM, TSP1 and CTGF | (13,14) |
| miR-106b-25 | BIM, p21, PTEN and p53 | (15-17) | |
| miR-221/222 | p27, p57, DDIT4, PTEN and TIMP3 | (18-20) | |
| miR-21 | PDCD4, PTEN, RHOB, RECK and TIMP3 | (21-24) | |
| TsmiRs | miR-15a/miR-16-1 | BCL2, CCND1, CCND3, CCNE1, CDK6, VEGF, FGF2 and FGFR1 | (25-30) |
| miR-143/145 | RAS, c-Myc, BNIP3, FSCN1, OCT4, SOX2 and KLF4 | (31-36) | |
| miR-200 family and miR-205 | ZEB1 and ZEB2 | (37) | |
| miR-101 | EZH2 | (38) | |
| miR-449a | HDAC-1 | (39) |