Table 2.

Pharmacokinetic properties of glimepiride

Absorption	Completely absorbed after oral administration within 1 hour of administration; significant absorption occurs: plasma protein binding is 99.4% and volume of distribution is 8.8 L. Accumulation does not occur after multiple doses.
Metabolism	The drug is primarily metabolized in the liver by CYP2C9 to the active M1 (hydroxyl) metabolite and then to inactive M2 (carboxy) metabolite.
Excretion	The main route of excretion is through kidneys. A total of 60% of the metabolites are excreted in urine (predominantly M1) and remainder in feces (predominantly M2).