Table 5.

Test for differences in change in each RAND 36-item Short Survey quality-of-life domain per 6 months after diagnosis over 2-year follow-up, by diagnostic group.

	Change per 6 Months after Diagnosis (95% CI)			P value Test for Differences in Change between:
	Controls	DCIS	EIBC	DCIS and EIBC	DCIS and Controls	EIBC and Controls
PF	−0.29 (−0.64, 0.06)	0.75 (−0.09, 1.60)	0.33 (−0.32, 0.98)	0.38	0.08	0.31
RP	−0.33 (−1.14, 0.49)	7.27 (5.25, 9.30)	9.22 (7.62, 10.82)	0.10	< 0.0001	< 0.0001
EWB	−0.48 (−0.81, −0.14)	1.49 (0.84, 2.14)	1.85 (1.29, 2.40)	0.32	< 0.0001	< 0.0001
RE	−0.73 (−1.44, −0.01)	3.48 (1.88, 5.08)	3.67 (2.31, 5.03)	0.84	< 0.0001	< 0.0001
SF	−0.50 (−1.02, 0.02)	2.52 (1.42, 3.62)	3.91 (3.02, 4.79)	0.03	< 0.0001	<0.0001
GH	−0.11 (−0.44, 0.22)	−0.01 (−0.69, 0.68)	0.19 (−0.39, 0.76)	0.61	0.98	0.52
E/F	−0.24 (−0.64, 0.17)	2.22 (1.31, 3.14)	2.46 (1.72, 3.19)	0.65	< 0.0001	< 0.0001
Pain	−0.12 (−0.61, 0.37)	0.68 (−0.42, 1.77)	1.71 (0.82, 2.59)	0.10	0.23	< 0.001

CI Confidence Interval, DCIS ductal carcinoma in situ, EIBC early invasive breast cancer, PF physical functioning, RP role limitations due to physical problems, EWB emotional well being, RE role limitations due to emotional problems, SF social functioning, GH general health, E/F energy/fatigue

Generalized Estimating Equation models were adjusted for age, race, education, marital status, BMI, social support, comorbidity, history of depression, menopausal symptoms, and hormone replacement therapy use