Table 5.
Univariate and multivariate analysis of factors affecting cause specific survival
|
T1N0 |
T2N0 |
|||||||
|---|---|---|---|---|---|---|---|---|
| Parameters | Event/pts |
Uni-variate |
Multivariate analysis |
Event/pts |
Uni-variate |
Multivariate analysis |
||
| P value | Hazard ratio (95% CI) | P value | P value | Hazard ratio (95%CI) | P value | |||
| Age |
|
|
|
|
|
|
|
|
| <61 |
4/142 |
0.897 |
- |
NS |
0/90 |
0.224 |
- |
NS |
| 61-70 |
3/153 |
|
|
|
3/103 |
|
|
|
| >70 |
3/138 |
|
|
|
2/69 |
|
|
|
| Sex |
|
|
|
|
|
|
|
|
| Male |
10/413 |
0.459 |
- |
NS |
5/249 |
0.61 |
- |
NS |
| Female |
0/20 |
|
|
|
0/13 |
|
|
|
| Substage |
|
|
|
|
|
|
|
|
| T1A |
7/324 |
0.53 |
- |
NS |
NA |
- |
- |
- |
| T1B |
3/109 |
|
|
|
|
|
|
|
| Grade |
|
|
|
|
|
|
|
|
| Well diff |
3/154 |
0.825 |
- |
NS |
1/63 |
0.721 |
|
NS |
| Mod diff |
7/273 |
|
|
|
3/179 |
|
|
|
| Poorly diff |
0/6 |
|
|
|
1/20 |
|
|
|
| Impaired Cord mobility |
|
|
|
|
|
|
|
|
| yes |
NA |
- |
- |
- |
1/51 |
0.84 |
|
NS |
| No |
|
|
|
|
4/211 |
|
|
|
| Subglottic Extension |
|
|
|
|
|
|
|
|
| Yes |
NA |
- |
- |
- |
2/80 |
0.56 |
- |
NS |
| No |
|
|
|
|
3/182 |
|
|
|
| Hb (g/ dL) |
|
|
|
|
|
|
|
|
| < 13.0 |
1/45 |
0.76 |
- |
NS |
1/28 |
0.022* |
2.8 (1.5-7.8) |
0.028* |
| ≥ 13.0 |
9/388 |
|
|
|
4/234 |
|
1 |
|
| AC |
|
|
|
|
|
|
|
|
| No |
2/236 |
0.026* |
1 |
0.045* |
1/76 |
0.712 |
- |
NS |
| Yes |
8/197 |
|
3.7 (1.20-18.5) |
|
4/186 |
|
|
|
| Field size (cm2) |
|
|
|
|
|
|
|
|
| <30.5 |
6/217 |
0.642 |
- |
NS |
0 |
0.42 |
- |
NS |
| 30.5- 35.5 |
4/165 |
|
|
|
2/106 |
|
|
|
| > 35.5 |
0/53 |
|
|
|
3/156 |
|
|
|
| Dose size |
|
|
|
|
|
|
|
|
| 2.0 Gy |
7/256 |
0.463 |
- |
NS |
4/176 |
0.513 |
- |
NS |
| 2.5 Gy |
3/177 |
|
|
|
1/86 |
|
|
|
| BED Gy15 |
|
|
|
|
|
|
|
|
| < 65.0 |
8/315 |
0.661 |
- |
NS |
4/175 |
0.534 |
- |
NS |
| ≥ 65.0 |
2/118 |
|
|
|
1/87 |
|
|
|
| Tx period |
|
|
|
|
|
|
|
|
| 1983- 1990 |
1/115 |
0.287 |
- |
NS |
0/75 |
0. 334 |
- |
NS |
| 1991- 2000 |
6/224 |
|
|
|
4/142 |
|
|
|
| 2001- 2005 | 3/94 | 1/45 | ||||||
Abbreviations: pts = patients; Hb = hemoglobin; Tx = treatment; diff = differentiated AC = anterior commissure; BED = biologically effective dose; * = statistically significant; NS = not significant.