Table 2.
Biological pathways identified by GeneGO metacore pathway analysis as differing over time between BD subjects who responded or failed to respond to treatment with lithium
|
GeneGO Process Networks for genes showing significant group x time interaction | ||
|---|---|---|
| Overall | p-Value | |
| 1 |
Apoptosis_Anti-Apoptosis mediated by external signals |
0.013 |
| 2 |
Apoptosis_Apoptotic mitochondria |
0.055 |
| 3 |
Cytoskeleton_Actin filaments |
0.055 |
| 4 |
Apoptosis_Endoplasmic reticulum stress pathway |
0.068 |
| 5 |
Cell cycle_Core |
0.110 |
| 6 |
Protein folding_Folding in normal condition |
0.117 |
| 7 |
Cell cycle_G1-S Interleukin regulation |
0.123 |
| 8 |
Development_Hemopoiesis, Erythropoietin pathway |
0.143 |
| 9 |
Immune response_BCR pathway |
0.147 |
| 10 |
Apoptosis_Apoptosis stimulation by external signals |
0.159 |
|
Week 4: down-regulated genes in Lithium responders vs. non-responders | ||
| 1 |
Apoptosis_Apoptotic mitochondria |
0.053 |
| 2 |
Apoptosis_Endoplasmic reticulum stress pathway |
0.060 |
| 3 |
Signal transduction_Nitric oxide signaling |
0.061 |
| 4 |
Apoptosis_Anti-Apoptosis mediated by external signals by Estrogen |
0.068 |
| 5 |
Protein folding_Folding in normal condition |
0.081 |
| 6 |
Proteolysis_Proteolysis in cell cycle and apoptosis |
0.085 |
| 7 |
Development_Hemopoiesis, Erythropoietin pathway |
0.092 |
| 8 |
Apoptosis_Apoptosis stimulation by external signals |
0.098 |
| 9 |
Proliferation_Negative regulation of cell proliferation |
0.123 |
| 10 |
Cell adhesion_Amyloid proteins |
0.127 |
|
Week 4: up-regulated genes in Lithium responders vs. non-responders | ||
| 1 |
Cell adhesion_Glycoconjugates |
0.010 |
| 2 |
Apoptosis_Anti-Apoptosis mediated by external signals via PI3K/AKT |
0.017 |
| 3 |
Autophagy_Autophagy |
0.053 |
| 4 |
Signal transduction_Androgen receptor signaling cross-talk |
0.069 |
| 5 |
Signal transduction_ERBB-family signaling |
0.072 |
| 6 |
Cytoskeleton_Macropinocytosis and its regulation |
0.081 |
| 7 |
Inflammation_IL-13 signaling pathway |
0.087 |
| 8 |
Signal transduction_Leptin signaling |
0.098 |
| 9 |
Signal Transduction_Cholecystokinin signaling |
0.100 |
| 10 |
Inflammation_IL-4 signaling |
0.108 |
|
Week 6: down-regulated genes in Lithium responders vs. non-responders | ||
| 1 |
Cell cycle_Core |
0.027 |
| 2 |
Development_Hemopoiesis, Erythropoietin pathway |
0.036 |
| 3 |
Response to hypoxia and oxidative stress |
0.053 |
| 4 |
Transport_Synaptic vesicle exocytosis |
0.059 |
| 5 |
Cell cycle_G0-G1 |
0.149 |
| 6 |
Neurophysiological process_Long-term potentiation |
0.170 |
| 7 |
Blood coagulation |
0.193 |
| 8 |
Apoptosis_Anti-Apoptosis mediated by external signals by Estrogen |
0.202 |
| 9 |
Inflammation_IL-6 signaling |
0.238 |
| 10 |
Cell cycle_G1-S Interleukin regulation |
0.245 |
|
Week 6: up-regulated genes in Lithium responders vs. non-responders | ||
| 1 |
Development_Skeletal muscle development |
0.024 |
| 2 |
Cell adhesion_Attractive and repulsive receptors |
0.034 |
| 3 |
Cytoskeleton_Actin filaments |
0.034 |
| 4 |
Development_Neurogenesis:Axonal guidance |
0.056 |
| 5 |
Protein folding_ER and cytoplasm |
0.074 |
| 6 |
Protein folding_Response to unfolded proteins |
0.111 |
| 7 |
Apoptosis_Apoptotic mitochondria |
0.123 |
| 8 |
Apoptosis_Endoplasmic reticulum stress pathway |
0.138 |
| 9 |
Apoptosis_Anti-Apoptosis mediated by external signals by Estrogen |
0.156 |
| 10 | Protein folding_Folding in normal condition | 0.184 |
Pathway analysis was conducted for the entire group of 127 genes showing a significant group x time interaction, as well as for up-regulated and down-regulated genes separately at each of the time-points where significant differences were seen (4 weeks and 6 weeks after treatment initiation).