. Author manuscript; available in PMC: 2013 Aug 8.

Published in final edited form as: Sci Transl Med. 2012 Aug 8;4(146):146ra110. doi: 10.1126/scitranslmed.3003948

Table 1.

Antinociceptive effect of naltrexone.

Treatment	Naltrexone pretreatment (% maximal possible inhibition)
Treatment	0 mg/kg	0.3 mg/kg	3.0 mg/kg
Heroin (1 mg/kg)^*	100 ± 0	4 ± 3^†	8 ± 4^†
Buprenorphine (3 mg/kg)^*	82 ± 15	20 ± 9^†	22 ± 6^†
U50,488 (50 mg/kg)^‡	54 ± 11	51 ± 4	49 ± 7

Maximal effect at 20 min.

^†

P < 0.001, compared with controls (0 mg/kg).

^‡

Maximal effect at 40 min.